Human Oncology & Pathogenesis Program

The Adrienne Boire Lab

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Research

Adrienne A. Boire, MD, PhD

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

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VIDEO | 02:04

Inside My Lab: Adrienne Boire

Go inside the lab of Adrienne Boire from MSK's Human Oncology & Pathogenesis Program.
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The Adrienne Boire Lab

Featured News

Finding
Scientists Jan Remsik, Adrienne Boire, and Jessica Wilcox in the lab
MSK Researchers Learn What’s Driving ‘Brain Fog’ in People with COVID-19

The presence of inflammatory molecules in the cerebrospinal fluid appears to be causing many of the neurologic effects seen in people with COVID-19.
In the Lab
Adrienne Boire
Iron Fiends: Cancer Cells in Brain and Spinal Fluid Survive by Monopolizing a Nutrient

Researchers gain insight into leptomeningeal metastasis, a devastating complication of advanced cancer.
In the Lab
Adrienne Boire at the lab bench
Inspired by a Patient, a Doctor Finds Answers for a Devastating Cancer Complication

Research is providing new clues about how cancer spreads to spinal fluid, a condition called leptomeningeal metastasis.

Publications

Remsik J, Wilcox JA, Babady NE, McMillen TA, Vachha BA, Halpern NA, Dhawan V, Rosenblum M, Iacobuzio-Donahue CA, Avila EK, Santomasso B and A Boire 2021 Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients Cancer Cell 39:1-8

Noura J Choudhury NJ, Yang SR, Arcila M, Mohanty AS, Boire A and A Drilon 2020 Genomic Characterization of a RET Inhibitor-Resistant RET Fusion-Positive Lung Cancer by CSF Cell-Free DNA Hybrid Capture-Based Sequencing CO Precis Oncol 4:PO.20.00188

Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe’er D, Mazutis L and A Boire 2020 Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369(6501):276-282.

Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Seidman AD, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. 2020 Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases Neuro Oncol Jun 27

Malani R, Fleisher M, Kumthekar P, Lin X, Omuro A, Groves MD, Lin NU, Melisko M, Lassman AB, Jeyapalan S, Seidman A, Skakodub A, Boire A, DeAngelis LM, Rosenblum M, Raizer J and E Pentsova 2020 Cerebrospinal Fluid Circulating Tumor Cells as a Quantifiable Measurement of Leptomeningeal Metastases in Patients with HER2 Positive Cancer. Neuro-Oncology Jun 6.

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People

Adrienne A. Boire

Adrienne A. Boire, MD, PhD

  • Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
  • PhD, Tufts University, Boston, MA
  • MD, University of Chicago, Chicago, IL
646-888-3861
Office Phone
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Physician profile

Members

Kiana Chabot
Kiana Chabot

Research Technician

Ana Rita Lobato Cortesao Nobre
Ana Rita Lobato Cortesao Nobre

Research Fellow

Samantha De La Moneda
Samantha De La Moneda

Administrative Assistant

Morgan Freret
Morgan Freret

Resident, Radiation Oncology

David Gruber
David Gruber

Research Technician

Sara Haddock
Sara Haddock

Graduate Student, Cornell BCMB

Min Jun Li
Min Jun Li

Research Technician

Ahmed Osman
Ahmed Osman

Research Fellow

Jan Remsik, PharmD, PhD
Jan Remsik

Research Fellow

Jenna Snyder
Jenna Snyder

Graduate Student, GSK

Xinran Tong
Xinran Tong

Graduate Student, Cornell BCMB

Jessica Wilcox
Jessica Wilcox

Assistant Attending Neurologist

Lab Alumni
Majdi Alghader

Senior Research Technician

Giscard Barbier
Giscard Barbier

Administrative Assistant

Yudan Chi

Research Scholar

Camille Derderian

Laboratory Technician

Danielle Isakov
Danielle Isakov

Research Technician

Anestashia Melford
Anestashia Melford

Administrative Assistant

Fadi Saadeh
Fadi Saadeh

Research Fellow

Ugur Sener
Ugur Sener

Clinical Fellow

Lab Affiliations

Achievements

  • 2021 Geoffrey Beene Junior Faculty Chair
  • American Academy of Neurology Neuro Oncology Investigator Award (2020)
  • Pershing Square Sohn Prize (2019)
  • Pew Biomedical Scholar (2018)
  • Damon Runyon Clinical Investigator Award (2017)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

General Opportunities

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Adrienne A. Boire discloses the following relationships and financial interests:

  • Cancer Research UK
    Provision of Services (uncompensated)
  • Department of Defense/Congressionally Directed Medical Research Programs (CDMRP)
    Provision of Services (uncompensated)
  • Emory University
    Provision of Services
  • European Association of Neuro-Oncology (EANO)
    Provision of Services (uncompensated)
  • Medical University of Vienna
    Provision of Services (uncompensated)
  • Society for Neuro-Oncology (SNO)
    Provision of Services (uncompensated)
  • The Company of Biologists Ltd
    Provision of Services (uncompensated)
  • Washington University in St. Louis
    Provision of Services (uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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