Immunology Program

The Andrea Schietinger Lab

Research

Andrea Schietinger, PhD

Associate Member, Immunology Program, SKI

The goal of our laboratory is to understand when, why, and how immune cells become unresponsive to tumors. We develop genetic cancer mouse models that mimic cancer development in patients, investigate T cell responses over the course of tumor development, and define the molecular and epigenetic mechanisms that are responsible for the failure to control and eliminate tumors. Detailed information about our research is available at www.schietingerlab.com.

Featured News

Discovery of a Stem-like T Cell in Type 1 Diabetes Holds Potential for Improving Cancer Immunotherapy, Sloan Kettering Institute Scientists Say

Tuesday, November 30, 2021

As an autoimmune disease, Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy.

Sloan Kettering Institute Year in Review: 10 Noteworthy Science Breakthroughs of 2021

Tuesday, December 21, 2021

Take a look back at some of the biggest science stories from this past year.

In the Lab

Scientists at the Sloan Kettering Institute are learning why some immune cells are stubbornly hard to revive with immunotherapy.

Why Immune Cells Sometimes Fail to Fight Cancer (and What to Do about It)

Wednesday, May 17, 2017

By looking at how DNA is packaged in cells, scientists are teasing apart a long-standing conundrum about the immune response to cancer.

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Publications

TOX is a critical regulator of tumour-specific T cell differentiation. Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A. Nature. 2019 Jul;571(7764):270-274. doi: 10.1038/s41586-019-1324-y. Epub 2019 Jun 17.

Chromatin states define tumour-specific T cell dysfunction and reprogramming. Philip M, Fairchild L, Sun L, Horste EL, Camara S, Shakiba M, Scott AC, Viale A, Lauer P, Merghoub T, Hellmann MD, Wolchok JD, Leslie CS, Schietinger A. Nature. 2017 May 25;545(7655):452-456. doi: 10.1038/nature22367. Epub 2017 May 17.

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis. Schietinger A, Philip M, Krisnawan VE, Chiu EY, Delrow JJ, Basom RS, Lauer P, Brockstedt DG, Knoblaugh SE, Hämmerling GJ, Schell TD, Garbi N, Greenberg PD. Immunity. 2016 Aug 16;45(2):389-401. doi: 10.1016/j.immuni.2016.07.011. Epub 2016 Aug 9.

Schietinger A and Greenberg PD. “Tolerance and Exhaustion: Defining Mechanisms of T cell dysfunction.” (2014) Trends in Immunology, 35(2):51-60.

Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin CP, Zal T, and Schreiber H. “Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.” (2014) Oncoimmunology, 2013 Nov 1;2(11):e26677.

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People

Andrea Schietinger, PhD

Associate Member, Immunology Program, SKI

Cancer Immunologist Andrea Schietinger investigates immune responses to cancer, molecular mechanisms underlying tumor-induced T cell dysfunction, and new approaches for cancer immunotherapy.
PharmD, University of Hamburg, PhD, University of Chicago, Chicago, IL and University of Munich, Germany
Postdoctoral Training: Fred Hutchinson Cancer Research Center and University of Washington, Seattle

schietia@mskcc.org: Email Address
646-888-3754: Office Phone

Members

Andrea Schietinger

Principal Investigator, Associate Member

Gabriel Espinosa-Carrasco
Postdoctoral Fellow

Nadine Hernandez
Administrative Assistant

Prerak Trivedi, Research Fellow — Prerak Trivedi
Postdoctoral Fellow

Lab Alumni

Varintra Krisnawan

Research Technician

Mary Philip, MD PhD — Mary Philip
Senior Research Scientist

Nayanta Buchanan
Administrative Assistant

Heather Appleby, Research Technician — Heather Appleby
Research Technician

Lab Affiliations

Achievements

Pershing Square Sohn Award (2020)
Josie Robertson Investigator (2014-2019)
Cancer Research Institute Lloyd Old STAR Award (2019)
NIH Director’s Innovator Award (2017)
NIH/NCI K99/R00 Award (2015)

V Foundation for Cancer Research Award (2015)
William and Ella Owens Medical Research Foundation Award (2016)
Cancer Research Institute Irvington Fellowship (2012)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Tumor Immunology

Apply now

Get in Touch

schietia@mskcc.org

Lab Head Email
646-888-3754

Office Phone
646-422-0502

Office Fax
646-888-2635

Assistant: Nadine Hernandez
646-888-3334

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Andrea Schietinger discloses the following relationships and financial interests:

Sanquin
Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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