Structural Biology Program
The Christopher Lima Lab
Research
We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and post-transcriptional RNA maturation, processing and decay. We pursue biochemical approaches to reconstitute key intermediates or complexes in these pathways and combine them with single particle cryo-EM and x-ray crystallography in conjunction with genetics and biochemistry to elucidate structure/activity relationships.
Research Projects
Featured News
People
Christopher D. Lima, PhD
Chair, Structural Biology Program, SKI
- The Lima laboratory studies mechanisms underlying RNA processing as well as post-translational protein modification by ubiquitin-like proteins.
- PhD, Northwestern University
- limac@mskcc.org
- Email Address
- 212-639-8205
- Office Phone
Members
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Assistant to the Chair
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Member; Chair, Structural Biology Program, SKI
Senior Research Technician
Lab Alumni
Visiting Research Fellow
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Research Technician
Graduate Student and Research Fellow
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Senior Research Scientist
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Lab Affiliations
Achievements
- Member, National Academy of Sciences (2020)
- Fellow of the American Academy of Arts and Sciences (2017)
- Investigator, Howard Hughes Medical Institute (2013)
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2006)
- Scholar, Rita Allen Foundation (2003-2006)
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- Mayor's Award for Excellence in Science and Technology, NYC Department of Cultural Affairs and New York Academy of Sciences (2003)
- Young Investigator Award, Arnold and Mabel Beckman Foundation (1999-2002)
