Memorial Hospital Research Laboratories

The Ed Reznik Lab

Research

Ed Reznik, PhD

The mission of my research program is to address basic and clinical questions at the intersection of cancer metabolism, mitochondrial genetics, and cancer genomics, with a focus on translational applications in kidney cancer. Our research focuses on developing cutting-edge informatic and modeling approaches to address a single overarching question: how genotype and the tumor microenvironment cooperatively shape metabolic phenotypes.

Publications

Gorelick AN, Kim M, Chatila WK, La K, Hakimi AA, Berger MF, Taylor BS, Gammage PA, Reznik E. Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA. Nat Metab. 2021 Apr;3(4):558-570. doi: 10.1038/s42255-021-00378-8. Epub 2021 Apr 8. PMID: 33833465.

Gorelick AN, Sánchez-Rivera FJ, Cai Y, Bielski CM, Biederstedt E, Jonsson P, Richards AL, Vasan N, Penson AV, Friedman ND, Ho YJ, Baslan T, Bandlamudi C, Scaltriti M, Schultz N, Lowe SW, Reznik E†, Taylor BS†. Phase and context shape the function of composite oncogenic mutations. Nature. 2020 Jun;582(7810):100-103. doi: 10.1038/s41586-020-2315-8. Epub 2020 May 27. PMCID: PMC7294994.

Reznik E*†, Luna A*, Aksoy BA, Liu EM, La K, Ostrovnaya I, Creighton CJ, Hakimi AA, Sander C. A landscape of metabolic variation across tumor types. Cell Systems. 2018; S2405-4712(17)30589-6.

Reznik E*†, Christodoulou D*, Goldford JE, Briars E, Sauer U, Segrè D, Noor E. Genome-scale architecture of small molecule regulatory networks and the fundamental tradeoff between regulation and enzymatic activity. Cell Rep. 2017;20(11): 2666–2667. PMCID: PMC5600504

Hakimi AA*, Reznik E*, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJ. An integrated metabolic atlas of clear cell renal cell carcinoma. Cancer Cell. 2016;29(1):104–116. PMCID: PMC4809063.

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