Chemical Biology Program

The Heeseon An Lab

Research

Heeseon An, PhD

Human cells orchestrate up to ~20,687 proteins to maintain cell growth and survival. Upon environmental change, cells dynamically remodel their proteomic landscape by two simultaneous processes: enhancing the synthesis of proteins that respond to the altered cellular conditions and degrading a subset of the pre-existing proteome. Any defect in this nature’s fine-tuned system hampers regulated cell growth as exemplified by cancer and neurodegenerative disorders. To fully understand the underlying pathology of the dysregulated proteostasis system, Heeseon An’s lab studies the regulatory mechanisms of protein translation (ribosome) and degradation processes (the ubiquitin proteasome system and autophagy) in health and disease. Importantly, we develop chemical, biological, and proteomics tools to enable quantitative analyses of the cell biological events.

Publications

An, H.*; Ordureau, A.*; Koerner, M.; Paulo, J.A.; Harper, J.W. (2020) Systematic Quantitative Analysis of Ribosome Inventory During Nutrient Stress. Nature, 583, 303-309. * equal contribution

Ordureau, A., Paulo, J.A., Zhang, J., An, H., Swatek, K.N., Cannon, J.R., Wan, Q., Komander, D., Harper J.W. (2020) Global landscape and dynamics of Parkin and USP30-dependent ubiquitylomes in iNeurons during mitophagic signaling. Molecular Cell, 77, 1124-1142

An, H.; Harper, J.W. (2020) Ribosome Abundance Control Via the Ubiquitin-Proteasome System and Autophagy. J. Mol. Biol. 432, 170-184, review article

An, H.; Ordureau, A.; Paulo, J.A.; Shoemaker, C.J.; Denic, V.; Harper, J.W. (2019) TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress, Molecular Cell, 74, 891-908.

An, H.; Harper, J.W. (2018) Systematic Analysis of Ribophagy in Human Cells Reveals Bystander Flux During Selective Autophagy, Nat. Cell Biol., 20, 135-143.

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People

Heeseon An, PhD

Heeseon An’s lab develops chemical, biological, and proteomics tools to study protein homeostasis of sub-cellular organelles.
BS and MS, Chemistry, Seoul National University
PhD, Chemistry, Northwestern University
Postdoc, Cell Biology, Harvard Medical School

AnH@mskcc.org: Email Address
646-888-3417 (ZRC-2003): Office Phone
Download CV: PDF File

Members

Lab Alumni

Mel-Quann Hodge

Administrative Assistant

Lab Affiliations

Achievements

Josie Robertson Investigator (2020-2025)

Open Positions

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Career Opportunities

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Get in Touch

AnH@mskcc.org

Lab Head Email
646-888-3417 (ZRC-2003)

Office Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Heeseon An discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

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