Human Oncology & Pathogenesis Program

The Jorge Reis-Filho Lab

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Research

Jorge S. Reis-Filho, MD, PhD

My laboratory focuses on the discovery of the underlying genetic traits and dependencies of breast cancers based on a combination of traditional pathologic approaches with genomics, functional genomics and artificial intelligence to devise a taxonomy system for these tumors that more accurately reflects their biology and therapeutic vulnerabilities.

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The Jorge Reis-Filho Lab

Featured News

Nadeem Riaz (left) and Jorge Reis-Filho (right)
For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment

Human data and results from mouse experiments suggest that people with BRCA2 mutations may respond well to immunotherapy drugs.
In the Lab
Black-and-white microscopic image of cell from human granular cell tumor
A Study of Rare Tumors Uncovers the Presence of Tumor-Suppressing Genes

Studying the genes of granular cell tumors has revealed a previously unknown process through which cells can turn cancerous.
In the News
Welcome sign at the San Antonio Breast Cancer Symposium
Breast Cancer Updates: Evaluating Prostate Cancer Drugs, Developing Better Predictive Tools, and Calculating Recurrence

Summary More than 20 MSK physicians and researchers presented work at an annual breast cancer conference in San Antonio. The San Antonio Brea...

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Publications

Martelotto LG, Baslan T, Kendall J, Geyer FC, Burke KA, Spraggon L, Piscuoglio S, Chadalavada K, Nanjangud G, Ng CK, Moody P, D’Italia S, Rodgers L, Cox H, da Cruz Paula A, Stepansky A, Schizas M, Wen HY, King TA, Norton L, Weigelt B, Hicks JB, Reis-Filho JS. Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples. Nat Med 2017; 23:376-385. PMCID: PMC5608257.

Razavi P, Li BT, Brown DN, Jung B, Hubbell E, Shen R, Abida W, Juluru K, De Bruijn I, Hou C, Venn O, Lim R, Anand A, Maddala T, Gnerre S, Vijaya Satya R, Liu Q, Shen L, Eattock N, Yue J, Blocker AW, Lee M, Sehnert A, Xu H, Hall MP, Santiago-Zayas A, Novotny WF, Isbell JM, Rusch VW, Plitas G, Heerdt AS, Ladanyi M, Hyman DM, Jones DR, Morrow M, Riely GJ, Scher HI, Rudin CM, Robson ME, Diaz LA Jr, Solit DB, Aravanis AM, Reis-Filho JS. High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants. Nat Med 2019; 25:1928-1937. PMCID: PMC7061455.

Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS. Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nat Genet 2014; 46:1166-9.

Pareja F, Brandes AH, Basili T, Selenica P, Geyer FC, Fan D, Da Cruz Paula A, Kumar R, Brown DN, Gularte-Mérida R, Alemar B, Bi R, Lim RS, de Bruijn I, Fujisawa S, Gardner R, Feng E, Li A, da Silva EM, Lozada JR, Blecua P, Cohen-Gould L, Jungbluth AA, Rakha EA, Ellis IO, Edelweiss MIA, Palazzo J, Norton L, Hollmann T, Edelweiss M, Rubin BP, Weigelt B, Reis-Filho JS. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun 2018; 9:3533. PMCID: PMC6117336.

Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS. Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun 2018; 9:1816. PMCID: PMC5940840.

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People

Pictured: Jorge S. Reis-Filho

Jorge S. Reis-Filho, MD, PhD

  • Physician-scientist Jorge Reis-Filho focuses on the development of a predictive molecular classification for rare types of breast cancer and characterization of intratumor genetic heterogeneity in breast cancers.
  • MD, University of Porto (Portugal) and Federal University of Parana (Curitiba, Brazil)
  • PhD, University of Minho (Braga, Portugal) and The Institute of Cancer Research (London, UK)
reisfilj@mskcc.org
Email Address
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Physician profile

Members

Thais Basili
Thais Basili

Senior Research Assistant

Edaise Da Silva
Edaise Da Silva

Senior Research Scientist

Angela Del
Angela Del

Pathology Research Coordinator

Fatemeh Derakhshan
Fatemeh Derakhshan

Research Associate

Andrea Gazzo
Andrea Gazzo

Research Fellow

Jose Dopeso Gonzalez
Jose Dopeso Gonzalez

Senior Research Scientist

Timothy Hoang
Timothy Hoang

Research Technician

Antonio Marra
Antonio Marra

Research Associate

Fresia Pareja, MD, PhD
Fresia Pareja

Assistant Member, Department of Pathology

Ahamad Patel
Juber Ahamad Patel

Senior Computational Biologist

Pier Selenica
Pier Selenica

Senior Bioinformatics Research Technician

Mahsa Vahdatinia

Research Associate

Yonghong Xiao
Yonghong Xiao

Senior Research Assistant

Yingjie Zhu
Yingjie Zhu

Research Associate

Lab Alumni
Rui Bi, MD, PhD
Rui Bi

Research Fellow

François-Clement Bidard
François-Clement Bidard

Visiting Research Fellow

Kathleen Burke, PhD
Kathleen Burke

Research Fellow

Catherine Cowell
Catherine Cowell

Research Fellow

Ino de Brujin
Ino de Brujin

Bioinformatics Engineer

Maria Rosaria De Filippo
Maria Rosaria De Filippo

Research Fellow (Bioinformatics)

Leticia De Mattos-Arruda
Leticia De Mattos-Arruda

Research Fellow

Nicola Fusco
Nicola Fusco

Visiting Investigator

Felipe Correa Geyer, MD
Felipe Correa Geyer

Research Scientist

Elena Guerini-Rocco
Elena Guerini-Rocco

Visiting Investigator

Rodrigo Gularte-Merida
Rodrigo Gularte-Merida

Research Fellow

Jisun Kim, MD
Jisun Kim

Visiting Investigator

Christophe Lemetre, PhD
Christophe Lemetre

Research Fellow, Bioinformatician

Anqi Li
Anqi Li

Graduate Research Assistant

Raymond Lim, MSc
Raymond Lim

Bioinformatics Analyst

Luciano Martelotto
Luciano Martelotto

Research Fellow

Yifan Mo

Research Fellow (Bioinformatics)

Charlotte K.Y. Ng
Charlotte K.Y. Ng

Research Fellow (Bioinformatics)

Salvatore Piscuoglio
Salvatore Piscuoglio

Research Fellow

Caitlin E. Powell
Caitlin E. Powell

Research technician, Gynecology Research Laboratory, Department of Surgery

Anne Schultheis
Anne Schultheis

Visiting Investigator

Lab Affiliations

Achievements

  • Future Leaders in Cancer Research Prize, Cancer Research UK (2010)
  • Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2010)
  • Young Cancer Researcher Award -- Highly Commended, European Association for Cancer Research (2008)
  • CL Oakley Lectureship, Pathological Society of Great Britain and Ireland (2007)
  • Translational Research Award, British Association for Cancer Research (2007)
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  • Sir Anthony Driver Award, Breakthrough Breast Cancer, Institute of Cancer Research (2005)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Postdoctoral Research Fellow

We are currently seeking a postdoctoral research fellow to join our team of bioinformaticians, molecular biologists, and fellows in the development of methods for the analysis of novel approaches for single cell sequencing and cfDNA analysis.

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Jorge S. Reis-Filho discloses the following relationships and financial interests:

  • Belgian Volition
    Provision of Services
  • Eli Lilly and Company
    Provision of Services (uncompensated)
  • Goldman Sachs
    Provision of Services
  • Oncoclinicas do Brasil Servicos Medicos S.A.
    Fiduciary Role/Position; Ownership / Equity Interests
  • Paige.AI, Inc.
    Ownership / Equity Interests; Provision of Services
  • Repare Therapeutics
    Ownership / Equity Interests; Provision of Services
  • prIME Oncology
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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