P53 is a master regulator in cell homeostasis, it is the most studied tumor suppressor gene and its function is altered in almost all cancers. Restoration of p53 function mediates tumor regression by inductions of apoptosis, cell cycle arrest or senescence. There is growing evidence that the immune system plays an important role into the clearance of P53 reactivated cells. My present project is aimed to better delineate the role of p53 reactivation in inducing an immune response against tumor and confirm whether there is rational to combine with immunotherapeutic strategies to boost their mutual effect.