Memorial Hospital Research Laboratories

The Kayvan Keshari Lab

Share
Print
Back to Top

Research

Kayvan R. Keshari, PhD

The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized magnetic resonance, allowing us the ability to bring these approaches to the clinic.

View Lab Overview

The Kayvan Keshari Lab

Featured News

In the Lab
Kayvan Keshari
Fructose Could Play a Role in Targeting Leukemia

Leukemia cells metabolize fructose in a way that could make them easier to target with drugs.
Feature
Side-by-side images of brain MRIs.
New Imaging Technique Provides Snapshot of Brain Tumor Activity

A new imaging approach could shorten the time needed to determine whether a brain tumor treatment is working.
In the Clinic
Hyperpolarized MRI
Hyperpolarized MRI: A New Tool to Assess Treatment Response within Days

Hyperpolarized MRI could allow doctors to get a read on a tumor’s response to treatment quickly.

Publications

Lees H, Millan M, Ahamed F, Eskandari R, Granlund KL, Jeong S, Keshari KR. (2020) Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells. NMR Biomed. :e4447. doi: 10.1002/nbm.4447. Online ahead of print.

Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR. (2017) Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Sci Adv. Jun 16;3(6):e1700341

Salamanca-Cardona L, Shah H, Poot AJ, Correa FM, Di Gialleonardo V, Lui H, Miloushev VZ, Granlund KL, Tee SS, Cross JR, Thompson CB, Keshari KR. (2017) In vivo imaging of glutamine metabolism to the oncometabolite 2-hydroxyglutarate in IDH1/2 mutant tumors. Cell Metab. Dec. 5;26(6):830-841

Dong Y, Eskandari R, Ray C, Granlund K, Dos Santos-Cunha L, Miloushev V, Tee SS, Jeong S, Cheng EH, Hsieh JJ, Keshari KR. (2019) Hyperpolarized MRI Visualizes Warburg Effects and Predicts mTOR Inhibitor Treatment Response in Patient-Derived ccRCC Xenograft Models. Cancer Res. Jan. 1;79(1):242-250

Granlund KL, Tee SS, Vargas HA, Lyashenko SK, Reznik E, Fine S, Laudone V, Eastham JA, Touijer KA, Reuter VE, Gonen M, Sosoa RE, Nicholson D, Guo YW, Chen AP, Tropp J, Robb F, Hricak H, Keshari KR. (2019) Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell Metab. Sep;21(19):1550-4131

View All Publications

People

Pictured: Kayvan R. Keshari

Kayvan R. Keshari, PhD

  • Biochemist and imaging specialist Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer targets.
  • BA, University of California, Berkeley
  • PhD, University of North Carolina Chapel Hill
rahimikk@mskcc.org
Email Address
View physician profile
Physician profile

Members

Marjan Berishaj

Senior Research Technician

Ross Boltyanskiy, PhD
Ross Boltyanskiy

Research Fellow

Yolanda Bryce, MD
Yolanda Bryce

Assistant Attending

Rachel Chirayil
Rachel Chirayil

Technician

Quinlan Cullen
Quinlan Cullen

Graduate Student

Kofi Deh
Kofi Deh

Research Fellow

Nathaniel Kim
Nathaniel Kim

Research Fellow

Ana Mark
Ana Mark

Project Coordinator

Vesselin Miloushev
Vesselin Miloushev

Assistant Attending

Saket Patel

Research Scholar

Paola Porcari

Senior Research Scientist

Jessica Puzzuoli
Jessica Puzzuoli

Research Fellow

Thomas Ruan

Graduate Student

Tanya Schild
Tanya Schild

Research Fellow

Guannan Zhang

Research Fellow

Lab Alumni
H. Nikki Aldeborgh
H. Nikki Aldeborgh

Research Technician

Julio Alvarez
Julio Alvarez

Research Technician

Giuseppe Carlucci

Research Scholar

Andrew Cho
Andrew Cho

Graduate Student

Valentina Di Gialleonardo
Valentina Di Gialleonardo

Research Scholar

Lidia Dos Santos-Cunha
Lidia Dos Santos-Cunha

Research Fellow

Kristin Granlund
Kristin Granlund

Research Associate

Simran Gupta
Simran Gupta

Research Technician

Hannah Lees
Hannah Lees

Research Fellow

Alex Poot, PhD
Alex Poot

Research Fellow

Lucia Salamanca-Cardona
Lucia Salamanca-Cardona

Research Fellow

Sui Seng Tee
Sui Seng Tee

Research Fellow

Steven Truong
Steven Truong

Graduate Research Assistant

Lab Affiliations

Achievements

  • NIH Pathway Independent Award 2012

Lab News & Events

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Kayvan R. Keshari discloses the following relationships and financial interests:

  • Bruker BioSpin GmbH
    Provision of Services (uncompensated)
  • GreatPoint Ventures
    Provision of Services
  • NVision Imaging Technologies GmbH
    Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


View all disclosures

Related topics: