Memorial Hospital Research Laboratories

The Liang Deng Lab

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Research

Liang Deng, MD, PhD

Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma.

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Research Projects

Figure 1
The Liang Deng Lab

Featured News

Pictured: Liang Deng
At Work: Physician-Scientist Liang Deng

Physician-scientist Liang Deng cares for patients with melanoma and other skin cancers, and also conducts innovative research on poxviruses.
Imagination to Discovery

Three emerging investigators are tackling the mysteries of biology and cancer at Memorial Sloan Kettering.

Publications

Yang, N., J.M. Luna, P. Dai, Y. Wang, C.M. Rice, and L. Deng (2020) Lung type II epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs. BioRxiv 10.1101/2020.01.20.910927.

Shaw K.S., G.H. Nguyen, M. Lacouture, and L. Deng. (2017). Combination of imiquimod with cryotherapy for the treatment of penile intraepithelial neoplasia.  JAAD Case Rep. 3(6):546-549.

Dai, P., W. Wang, N. Yang, C. Serna-Tamayo, J.M. Ricca, D. Zamarin, S. Shuman, T. Merghoub,  J.D. Wolchok, and L. Deng. (2017). Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent DCs. Science Immunology 2, eaal1713: 1-15.

Gao, P., T. Zillinger, W. Wang, M. Ascano, P. dai, G. Hartmann, T. Tuschl, L Deng, W. Barchet, and D.J. Patel. (2014). Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. Cell Rep 8:1-9.

Dai, P., W. Wang, H. Cao, F. Avogadri, L. Dai, I. Drexler, J. A. Joyce, T. Merghoub, S. Shuman, and L. Deng. Modified vaccinia virus Ankara triggers type I IFN production in conventional dendritic cells via a cGAS/STING-dependent cytosolic DNA-sensing pathway. PLoS Pathogens 2014;10:e1003989.

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People

Liang Deng, MD, PhD

Liang Deng, MD, PhD

  • Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
dengl@mskcc.org
Email Address
646-888-6011
Office Phone
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Physician profile

Members

Liang Deng, MD, PhD
Liang Deng

Lab Head

Peihong Dai
Peihong Dai

Research Assistant

Weiyi Wang, PhD
Weiyi Wang

Senior Research Scientist

Shuaitong Liu
Shuaitong Liu

Research Technician

Gregory Mazo
Gregory Mazo

Research Fellow

Yi Wang
Yi Wang

Research Assistant

Ning Yang
Ning Yang

Senior Research Scientist

Lab Alumni
Biao Huang

Visiting Scholar

Zhaoyang Niu

Research Fellow

Cristian Serna-Tamayo

Medical Student Research Fellow

Lab Affiliations

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Liang Deng discloses the following relationships and financial interests:

  • Aduro Biotech, Inc
    Intellectual Property Rights
  • Imvaq Therapeutics
    Intellectual Property Rights; Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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