Developmental Biology Program
The Lorenz Studer Lab
Research
Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and application of human embryonic stem (ES) and human induced pluripotent (iPS) cells. Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant cell types for applications in human disease modeling or regenerative medicine.
Research Projects
Featured News
Publications
Giacomelli E, Vahsen BF, Calder EL, Xu Y, Scaber J, Gray E, Dafinca R, Talbot K, Studer L. Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation. Cell Stem Cell. 2022 Jan 6;29(1):11-35. doi: 10.1016/j.stem.2021.12.008.PMID: 34995492
Baggiolini A, Callahan SJ, Montal E, Weiss JM, Trieu T, Tagore MM, Tischfield SE, Walsh RM, Suresh S, Fan Y, Campbell NR, Perlee SC, Saurat N, Hunter MV, Simon-Vermot T, Huang TH, Ma Y, Hollmann T, Tickoo SK, Taylor BS, Khurana E, Koche RP, Studer L, White RM. Developmental chromatin programs determine oncogenic competence in melanoma. Science. 2021 Sep 3;373(6559):eabc1048. doi: 10.1126/science.abc1048. Epub 2021 Sep 3.PMID: 34516843
Kim TW, Piao J, Koo SY, Kriks S, Chung SY, Betel D, Socci ND, Choi SJ, Zabierowski S, Dubose BN, Hill EJ, Mosharov EV, Irion S, Tomishima MJ, Tabar V, Studer L. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021 Feb 4;28(2):343-355.e5. doi: 10.1016/j.stem.2021.01.005.PMID: 33545081
Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M, Claros N, Rosen S, Ramnarine K, Horn C, Fredrickson C, Wong K, Safford B, Kriks S, El Maarouf A, Rutishauser U, Henchcliffe C, Wang Y, Riviere I, Mann S, Bermudez V, Irion S, Studer L, Tomishima M, Tabar V. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell Stem Cell. 2021 Feb 4;28(2):217-229.e7. doi: 10.1016/j.stem.2021.01.004.PMID: 33545080
Guttikonda SR, Sikkema L, Tchieu J, Saurat N, Walsh RM, Harschnitz O, Ciceri G, Sneeboer M, Mazutis L, Setty M, Zumbo P, Betel D, de Witte LD, Pe’er D, Studer L. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease. Nat Neurosci. 2021 Feb 8. doi: 10.1038/s41593-020-00796-z. Online ahead of print.PMID: 33558694
People
Lorenz Studer, MD
Director, Center for Stem Cell Biology
- The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine.
- MD, Universitat Bern
- studerl@mskcc.org
- Email Address
- 212-639-6126
- Office Phone
Members
- 212-639-8510
- Lab Phone
- Princeton University
- Connecticut College
- Wellesley College
Lab Alumni
Lab Affiliations
Achievements
- ISSCR Achievement Award (2022)
- Jacob & Louise Gabbay Award in Biotechnology & Medicine (2018)
- Ogawa-Yamanaka Stem Cell Prize, Gladstone Institutes (2017)
- MacArthur Fellow (2015)
- Member, American Society of Clinical Investigation (2014)
Read more
- Annemarie Opprecht Parkinson Award, Annemarie Opprecht Foundation (2012)
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2005)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
Career Opportunities
Get in Touch
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Lab Head Email
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Office Phone
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Office Fax
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Lorenz Studer discloses the following relationships and financial interests:
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BlueRock Therapeutics
Intellectual Property Rights; Provision of Services -
Fujifilm Cellular Dynamics, Inc.
Intellectual Property Rights -
Luxa Biotechnology, LLC
Provision of Services
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Neurona Therapeutics
Ownership / Equity Interests; Provision of Services (uncompensated) -
Rumi Scientific, Inc.
Provision of Services (uncompensated) -
Vita Therapeutics, Inc.
Ownership / Equity Interests; Provision of Services (uncompensated)
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.