Immunology Program
The Marcel van den Brink Lab
Research
Immuno-oncology is increasingly becoming an important therapy for a variety of cancers. As Head of the Division of Hematologic Malignancies and an Attending Physician of the Adult Bone Marrow Transplantation Service, I see patients undergoing a bone marrow transplantation. In my lab, I study novel strategies to improve immune therapies for cancer patients with a special emphasis on the role of the intestinal microbiome in (patho)physiology and therapy, Chimeric Antigen Receptor T cell therapy, and regeneration of thymic function to improve T cell immunity.
Research Projects
Featured News
Publications
Smith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A, van den Brink MRM, Ruella M. Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy. Nat Med. 2022 Mar 14. doi: 10.1038/s41591-022-01702-9. Epub ahead of print. PMID: 35288695.
Miltiadous O, Waters NR, Andrlova H, Dai A, Nguyen CL, Burgos da Silva M, Lindner S, Slingerland J, Giardina P, Clurman A, Armijo GK, Gomes AL, Lakkaraja M, Maslak PG, Scordo M, Shouval R, Staffas A, O’Reilly RJ, Taur Y, Prockop S, Boelens JJ, Giralt S, Perales MA, Devlin SM, Peled JU, Markey KA, van den Brink MRM. Early intestinal microbial features are associated with CD4 T cell recovery after allogeneic hematopoietic transplant. Blood. 2022 Jan 21:blood.2021014255. doi: 10.1182/blood.2021014255. Epub ahead of print. PMID: 35061893.
People
Marcel R. M. van den Brink, MD, PhD
- Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution.
- MD, PhD, Universiteit Leiden
- vandenbm@mskcc.org
- Email Address
- 646-888-2304
- Office Phone
- View physician profile
- Physician profile
Members
- National and Kapodistrian University of Athens, Greece
- 646-888-2317
- Lab Phone
- Christian Medical College (MD), Vellore, India
- Muhlenberg College | Allentown, PA
- 646-888-2317
- Lab Phone
- 1. Bachelor of Science in Biological Sciences. Lehigh University. 2021.
- University of Connecticut, CT | Weill Cornell Graduate School of Medical Sciences, NY
- 646-888-2317
- Lab Phone
- Bachelors in Biological Sciences with a concentration in Pathobiology- Drexel University, Philadelphia, 2017-2021
- 646-888-2317
- Office Phone
- Colgate University | NY
- Gerstner Sloan Kettering Graduate School | NY
- 646-888-2317
- Lab Phone
- Albert Einstein College of Medicine | Bronx, New York
- MPH Candidate, New York University
- MPA, Columbia University
- Rutgers University
- MD: Technion, Israel Institute of Technology | Haifa, Israel
- PhD: Bar Ilan University | Ramat Gan, Israel
- Binghamton University
- CUNY Hunter College
- Pace University, Lienhard School of Nursing
- Binghamton University
- Monash University, Melbourne, Australia
- 646-888-2317
- Lab Phone
- Weill Cornell Graduate School of Medical Sciences
- 646-888-2317
- Lab Phone
- Technische Universität München - Medical School, Ludwig-Maximilians-Universität München - Medical School Undergraduate
- 646-888-2317
- Lab Phone
- BA from New York University
- MD from Robert Wood Johnson Medical School
- 646-888-2317
- Lab Phone
- Mysore Medical College (MD), Karnataka, India and Medizinische Hochschule Hannover (PhD), Hannover, Germany
- 646-888-2317
- Lab Phone
- Barnard College of Columbia University 2015
- 646-888-2317
- Lab Phone
- Oregon Health and Science University School of Medicine, Portland, Oregon
- 646-888-2317
- Lab Phone
- University of Nantes, France University Pierre et Marie Curie, France
- 646-888-2317
- Lab Phone
- MPA Candidate, Villanova University
- Rutgers University
- University of Puerto Rico BS
- Vanderbilt University School of Medicine MD, PhD
- Memorial Sloan Kettering Cancer Center Radiation Oncology Residency
- 646-888-2317
- Lab Phone
- Universidade Federal do Rio de Janeiro, UFRJ, Rio De Janeiro, Brazil
- Boston University, BA
- University of Michigan Ann Arbor
- 646-888-2317
- Lab Phone
- Ludwigs-Maximilians-University, Munich, Germany
- Harvard Medical School, Boston, MA
- University of Cape Town, Capetown, SA.
- 646-888-2317
- Office Phone
- Pace University
- Morgan State University
- Hokkaido University Graduate School of Medicine, Sapporo, Japan
- Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- (646) 888-2304
- Office Phone
- (646) 888-2317
- Lab Phone
- New York University
- 646-888-2304
- Office Phone
- 646-422-4052
- Office Fax
- University of Gothenburg, Sweden
- (646) 888-2304
- Office Phone
- (646) 888-2317
- Lab Phone
- 646-888-2317
- Office Phone
- 646-888-2317
- Lab Phone
- Chemical Engineering (PhD), NYU Polytechnic School of Engineering
- University of Perugia, Perugia, Italy
- 646-888-2317
- Lab Phone
- Monash University, Melbourne, Australia
- 646-888-2317
- Lab Phone
Lab Alumni
Achievements
- Head of the Division of Hematologic Malignancies at MSKCC (2008 - present)
- Royal Dutch Academy of Sciences (2020)
- International Society for Experimental Hematology: Till and McCulloch Lectureship Award (2015)
- Alan N. Houghton Chair in Immunology at MSKCC (2007)
- Howard Hughes Physician Scientist Award (1996)
Lab News & Events
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
Research Technician
Get in Touch
-
Lab Head Email
-
Office Phone
-
Office Fax
-
Lab Phone
-
Lab Fax
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Marcel R. M. van den Brink discloses the following relationships and financial interests:
-
Ceramedix
Provision of Services -
DKMS
Fiduciary Role/Position; Provision of Services -
Da Volterra
Provision of Services -
Garuda Therapeutics
Provision of Services -
GlaxoSmithKline
Provision of Services -
Juno Therapeutics
Intellectual Property Rights -
King Faisal Specialist Hospital & Research Centre
Provision of Services -
LyGenesis, Inc.
Provision of Services
-
MJH Life Sciences
Provision of Services -
Notch Therapeutics
Ownership / Equity Interests; Provision of Services -
Pluto Immunotherapeutics
Ownership / Equity Interests; Provision of Services (uncompensated) -
Priothera Limited
Provision of Services -
Rheos Medicines, Inc
Provision of Services -
Seres Therapeutics
Intellectual Property Rights; Ownership / Equity Interests; Provision of Services -
Smart Immune SAS
Provision of Services (uncompensated) -
WindMIL Therapeutics, Inc.
Provision of Services
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.