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Christina Leslie: Publications

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Ets transcription factor GABP controls T cell homeostasis and immunity. Luo CT, Osmanbeyoglu HU, Do MH, Bivona MR, Toure A, Kang D, Xie Y, Leslie CS, Li MO. Nat Commun. 2017 Oct 20;8(1):1062. doi: 10.1038/s41467-017-01020-6.

Chromatin states define tumour-specific T cell dysfunction and reprogramming. Philip M, Fairchild L, Sun L, Horste EL, Camara S, Shakiba M, Scott AC, Viale A, Lauer P, Merghoub T, Hellmann MD, Wolchok JD, Leslie CS, Schietinger A. Nature. 2017 May 25;545(7655):452-456. doi: 10.1038/nature22367. Epub 2017 May 17.

An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data. Carty M, Zamparo L, Sahin M, González A, Pelossof R, Elemento O, Leslie CS. Nat Commun. 2017 May 17;8:15454. doi: 10.1038/ncomms15454.

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Toska E, Osmanbeyoglu HU, Castel P, Chan C, Hendrickson RC, Elkabets M, Dickler MN, Scaltriti M, Leslie CS, Armstrong SA, Baselga J. Science. 2017 Mar 24;355(6331):1324-1330. doi: 10.1126/science.aah6893.

GuideScan software for improved single and paired CRISPR guide RNA design. Perez AR, Pritykin Y, Vidigal JA, Chhangawala S, Zamparo L, Leslie CS, Ventura A. Nat Biotechnol. 2017 Apr;35(4):347-349. doi: 10.1038/nbt.3804. Epub 2017 Mar 6.

Prediction of potent shRNAs with a sequential classification algorithm. Pelossof R, Fairchild L, Huang CH, Widmer C, Sreedharan VT, Sinha N, Lai DY, Guan Y, Premsrirut PK, Tschaharganeh DF, Hoffmann T, Thapar V, Xiang Q, Garippa RJ, Rätsch G, Zuber J, Lowe SW, Leslie CS, Fellmann C. Nat Biotechnol. 2017 Apr;35(4):350-353. doi: 10.1038/nbt.3807. Epub 2017 Mar 6.

Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs. Osmanbeyoglu HU, Toska E, Chan C, Baselga J, Leslie CS. Nat Commun. 2017 Jan 31;8:14249. doi: 10.1038/ncomms14249.

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Peng M, Yin N, Chhangawala S, Xu K, Leslie CS, Li MO. Science. 2016 Oct 28;354(6311):481-484. Epub 2016 Sep 29.