Structural Biology Program

The Stephen Long Lab

Research

Stephen B. Long, PhD

Member

Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development, and they are potential targets for diseases including immune disorders and cancer. Our discoveries lead to new understandings of the fundamental mechanisms of these proteins and guide efforts to control them using small molecule and biologic modulators for potential use as therapeutic agents.

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Voltage-dependent potassium channel and Two-pore domain potassium channel

X-ray structures of eukaryotic calcium, potassium, and chloride channels determined in the lab

Pictured: Stephen B Long Lab — Long Lab circa 2021

Featured News

In the Lab

A gray blob marked RAS linked to colorful rods marked ICMT

Deciphering How Membrane Enzymes Work, with a Little Help from Beetles

Wednesday, January 17, 2018

The atomic structure of an elusive type of membrane protein has finally been solved by scientists at the Sloan Kettering Institute.

Profile

Pictured: Stephen Long & Alexandria Miller

At Work: Structural Biologist Stephen Long

Thursday, November 7, 2013

Stephen Long works to understand how proteins work by determining what they look like in three dimensions.

Q&A

3D Shape of an Ion Channel Revealed

Wednesday, February 8, 2012

Structural biologist Stephen Long talks about how his team used x-ray crystallography to discover the structure of an ion channel called K2P1.

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Publications

Hou, X.*, Outhwaite, I.R.*, Pedi, L., and Long, S.B. (2020). Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife 9. (Abstract | Open Conformation Cryo-EM map & Atomic Coordinates). *X. Hou and I.R. Outhwaite are co-first authors.

Wang, C., Jacewicz, A., Delgado, B.D., Baradaran, R., and Long, S.B. (2020). Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife 9. (Abstract | Holocomplex Cryo-EM map & Atomic Coordinates | MICU1-MICU2 complex Cryo-EM map & Atomic Coordinates)

Wang, C.*, Baradaran, R.*, and Long, S.B. (2020). Structure and Reconstitution of an MCU-EMRE Mitochondrial Ca²⁺ Uniporter Complex. J Mol Biol 432, 5632-5648. (Abstract | MCU-EMRE Cryo-EM map & Atomic Coordinates). *C. Wang and R. Baradaran are co-first authors.

Miller, A. N.*, Vaisey, G.*, & Long, S. B. (2019). Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife (Abstract | open state Cryo-EM map & Atomic Coordinates). *A. N. Miller and G. Vaisey are co-first authors.

Vaisey, G., & Long, S. B. (2018). An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. The Journal of General Physiology, jgp.201812190. (Abstract)

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People

Stephen B. Long, PhD

Member

The Long laboratory discovers the atomic mechanisms of ion channels and enzymatic membrane proteins with an eye to using these discoveries to benefit humanity.
BA, Physics, Amherst College, 1994
PhD, Biochemistry, Duke University, 2001
Postdoc, Rockefeller University, 2007

longs@mskcc.org: Email Address
212-639-2903: Office Phone

Members

Xiaowei Hou, PhD — Xiaowei Hou
Senior Research Scientist

Agata Jacewicz
Senior Research Scientist

George Vaisey, MBiochem — George Vaisey
Graduate Student

Pictured: David J. Van Dongen — David J. Van Dongen
Graduate Student

Lab Alumni

Veronica Kane-Dickson

Postdoctoral Fellow

Pictured: David Kerr — David Kerr
Undergraduate Researcher

Shana Burstein

Research Technician

Pictured: Alexandria Miller — Alexandria N. Miller
Postdoctoral Fellow

Lab Affiliations

Achievements

Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Postdoctoral Fellow Positions

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Get in Touch

longs@mskcc.org

Lab Head Email
212-639-2903

Office Phone
212-639-2959

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Stephen B. Long discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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